Rejected

Although progress has been made in the regulation of hypertension over the past decades, the USA and some other countries have faced a significant rise in incidence of chronic pain management cases during the same period. Studies of the relationship between pain and blood pressure (BP) regulations propose that these two processes may be interconnected. Studies of effects of antihypertensive treatment on pain in general and its chronification have never been reviewed.

Colloid cysts are benign and rare tumors of the brain. The growth rates of these tumors are unpredictable. There have been many factors attributed for sudden symptomatic presentation in colloid cyst. These cysts can increase in size and obstruct the Cerebrospinal fluid pathways producing obstructive hydrocephalus. Consequently, this can manifest as acute severe headaches followed by deterioration in consciousness or even sudden death in patients. Sudden symptomatic presentation of patients with colloid cysts during air travel have been reported sparsely in the literature. In this report, we describe such a patient with colloid cyst who had acute severe headache and deterioration in consciousness during air travel. The physiologic effects of the cabin pressure and high altitude on the intracranial pressure is discussed along with review of literature.

The caudal thoracic paravertebral (CTPV) block is a regional anesthesia technique currently used in human medicine to provide analgesia in abdominal surgical procedures.

The fundamental design of perineural catheters has changed little since they were first introduced WHAT THIS ARTICLE TELLS US THAT IS NEW: A novel catheter attached to the back of a suture-shaped needle can be inserted under ultrasound guidance to provide popliteal-sciatic nerve blockadeIn the first two days after foot and ankle surgery, analgesia provided using the suture-type catheters was found to be noninferior to that provided by conventional through-the-needle catheters BACKGROUND:: The basic perineural catheter design has changed minimally since inception, with the catheter introduced through or over a straight needle. The U.S. Food and Drug Administration recently cleared a novel perineural catheter design comprising a catheter attached to the back of a suture-shaped needle that is inserted, advanced along the arc of its curvature pulling the catheter past the target nerve, and then exited through the skin in a second location. The authors hypothesized that analgesia would be noninferior using the new versus traditional catheter design in the first two days after painful foot/ankle surgery with a primary outcome of average pain measured with the Numeric Rating Scale.

The opioid epidemic is a recent focus of national initiatives to reduce opioid misuse and related addiction. As interstitial cystitis (IC) is a chronic pain state at risk for narcotic use, we sought to assess opioid prescription use in patients with IC.

Achieving long-lasting surgical site anesthesia can be problematicCryoneurolysis is effective in providing long-lasting analgesia, but current techniques are nonselective for neural tissue WHAT THIS ARTICLE TELLS US THAT IS NEW: Using a rat sciatic nerve block model, an injectable biocompatible ice slurry preparation was shown to provide analgesic effects for at least 60 daysDisruption of myelin sheaths recovered by 112 days after injections, suggesting that the slurry-induced cryoneurolysis is reversibleProviding sustained analgesia using injected ice slurries may be possible BACKGROUND:: Postoperative pain caused by trauma to nerves and tissue around the surgical site is a major problem. Perioperative steps to reduce postoperative pain include local anesthetics and opioids, the latter of which are addictive and have contributed to the opioid epidemic. Cryoneurolysis is a nonopioid and long-lasting treatment for reducing postoperative pain. However, current methods of cryoneurolysis are invasive, technically demanding, and are not tissue-selective. This project aims to determine whether ice slurry can be used as a novel, injectable, drug-free, and tissue-selective method of cryoneurolysis and resulting analgesia.

Carotid artery stent placement is widely performed for treatment of carotid stenosis. The purpose of this study is to present our observations on cerebral vasoconstriction in ipsilateral anterior circulation during immediate poststenting angiography in patients with near-total occlusion of the proximal ICA.

To help clinicians identify and treat patients with tumor-induced osteomalacia (TIO) resulting from a phosphaturic mesenchymal tumor, mixed connective tissue variant (PMTMCT).

Small fibre neuropathy is a disorder of the peripheral nervous system for which main clinical manifestation is chronic neuropathic pain, often accompanied by alterations of the autonomic nervous system. This disease affects the small diameter myelinated (Aδ) and non-myelinated nerve fibres (C). Its causes are primary or secondary, such as metabolism defects, infection, and autoimmune, neurological or toxic diseases, among others. Routine neurophysiological tests are usually negative. Diagnosis can be made with complementary tests which are difficult to access from Primary Health Care. These include microneurography, and the sensory stimulation test; but the most used technique is the skin biopsy. Treatment is directed at the causes and the neurological symptoms. Due to the variability of symptoms that can be presented, the importance of being aware of this condition is emphasised in order to reach a diagnosis and offer the appropriate treatment.

To replicate and extend previous research by examining, among a larger sample, the effectiveness of a Whole Health Primary Care Pain Education and Opioid Monitoring Program (PC-POP) at increasing adherence to the Veteran Affairs/Department of Defense (VA/DoD) recommended guidelines for long-term opioid therapy among chronic noncancer patients seen in primary care-medications, hospitalization, monitoring/safety, assessment, and nonpharmacological pain treatment referrals.