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A Novel Virtual Reality Technique (Cervigame®) Compared to Conventional Proprioceptive Training to Treat Neck Pain: A Randomized Controlled Trial.

Despite the potential benefits of virtual reality technology in physical rehabilitation, only a few studies have evaluated the efficacy of this type of treatment in patients with neck pain.

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Gait speed and gait asymmetry in individuals with chronic idiopathic neck pain.

Recent studies have shown that individuals with chronic idiopathic neck pain (CINP) exhibit altered spatiotemporal gait parameters. Problems arising from the neck joints and related soft tissues, and most mechanical neck pain appear asymmetric. However, whether individuals with CINP have an asymmetric gait has not been clarified.

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Behavioral therapy for acute post-surgical phantom limb pain in a young adult with osteosarcoma.

Phantom limb pain (PLP) is one of the most difficult chronic pain syndromes to treat. Pain intensity can be extremely high with profound effects on quality of life . Unfortunately, pharmacologic interventions leave up to 50% of patients with chronic PLP . Behavioral treatments such as motor imagery and mirror therapy are promising in reducing PLP , but are not customarily utilized during the acute post-surgical timeframe when symptoms first occur. This article is protected by copyright. All rights reserved.

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Analgesic Efficacy of Tramadol Compared With Meloxicam in Ducks () Evaluated by Ground-Reactive Forces.

The purpose of this study was to determine the efficacy of tramadol and meloxicam in an induced, temporary arthritis model in ducks as assessed by ground-reactive forces measured by a pressure-sensitive walkway (PSW) system. Twelve ducks () were randomly separated into 3 equal groups of 4 birds each: water control, tramadol treatment, and meloxicam treatment. Baseline measurements were collected by having all ducks walk along a 3-m-long PSW in a custom-built corral before anesthesia and induction of arthritis. Arthritis was induced in all groups through injection, under anesthesia, of a 3% monosodium urate (MSU) solution into the intertarsal joint. One hour after MSU injection, birds were orally gavage fed 1 mL of tap water (control), tramadol (30 mg/kg), or meloxicam (1 mg/kg). After treatments, all ducks were reevaluated on the PSW at 1, 2, 3, 4, 8, and 24 hours post-MSU injection. The difference in maximum force was significantly greater in the control group than in both the tramadol- ( = .006) and meloxicam-treated ( = .03) individuals. Post hoc comparisons revealed differences between control and treated birds occurred only at the 3- and 4-hour time points after administration. No differences were found in the absolute difference in maximum force between tramadol- and meloxicam-treated birds at any time point > .05). Results of this study support the hypothesis that tramadol (30 mg/kg PO) and meloxicam (1 mg/kg PO) improve certain objective variables in an induced arthritis model in ducks. Our findings also support studies in other avian species that determined that both tramadol and meloxicam are effective analgesic drugs in some birds.

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The Use of Beetroot as Natural Solutions for Reducing Inflammation – Case Studies from Thailand (P12-046-19).

Introduction: Inflammation is a complex biological response of the body tissues to foreign particles or pathogens.Research shows that an alkaline state maintained by the cells is healthier while an acidic pH increases the risk for numerous problems including chronic inflammation. The usual adverse effects of the anti-inflammatory drugs, necessitate the search for novel compounds of herbal origin. Red beetroot (Beta vulgaris rubra), is a vegetable plant known to possess various beneficial properties and is considered as a promising therapeutic tool in a range of clinical pathologies associated with oxidative stress and inflammation due to the betalain pigments contained. The present study refers to three cases suggesting options in which beetroot might be used to handle in different situations of inflammation.

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Thoracoscopic thymectomy – The method of choise in surgical treatment of non-invasive thymomas.

Thymomas are very rare malignances, with an estimated incidence of 0.15 cases per 100.000. Metastases of Thymoma are usually involved the pleura, pericardium or diaphragm, whereas the probability of extrathoracic metastases are extremely low. Success in the treatment of thymomas mainly depends on the radicalism of the performed operation.

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The Medial Patellofemoral Ligament Is a Dynamic and Anisometric Structure: An In Vivo Study on Length Changes and Isometry.

Medial patellofemoral ligament (MPFL) reconstruction is associated with a high rate of complications, including recurrent instability and persistent knee pain. Technical errors are among the primary causes of these complications. Understanding the effect of adjusting patellofemoral attachments on length change patterns may help surgeons to optimize graft placement during MPFL reconstruction and to reduce graft failure rates.

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AK106-001616, a potent and selective inhibitor of cytosolic phospholipase A2: in vivo efficacy for inflammation, neuropathic pain, and pulmonary fibrosis.

AK106-001616 is a novel, potent, and selective inhibitor of the cytosolic phospholipase A2 (cPLA2) enzyme. Unlike traditional non-steroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors, AK106-001616 reduced prostaglandin (PG) E2 and leukotriene (LT) B4 production by stimulated cells. The suppression of PGE2 and LTB4 production was also confirmed using an air pouch model in rats administered a single oral dose of AK106-001616. AK106-001616 alleviated paw swelling in a rat adjuvant-induced arthritis (AIA) model. The Emax of the inhibitory effect of AK106-001616 was comparable with that of naproxen on paw swelling in a rat AIA model. Meanwhile, the inhibitory effect of AK106-001616 was more effective than that of naproxen in the mouse collagen antibody-induced arthritis model with LTs contributing to the pathogenesis. AK106-001616 dose-dependently reversed the decrease in paw withdrawal threshold not only in rat carrageenan-induced hyperalgesia, but also in a rat neuropathic pain model induced by sciatic nerve chronic constriction injury (CCI). However, naproxen and celecoxib did not reverse the decrease in the paw withdrawal threshold in the CCI model. Furthermore, AK106-001616 reduced the disease score of bleomycin-induced lung fibrosis in rats. In addition, AK106-001616 did not enhance aspirin-induced gastric damage in fasted rats, did not increase blood pressure, and did not increase the thromboxane A2/PGI2 ratio that is thought to be an underlying mechanism of thrombotic cardiovascular events increased by selective cyclooxygenase-2 inhibitors. Taken together, these data demonstrate that oral AK106-001616 may provide valuable effects for wide indications without attendant gastrointestinal and cardiovascular risks. SIGNIFICANCE STATEMENT: Idiopathic pulmonary fibrosis is a progressive and fatal interstitial disorder of the lung parenchyma. In 2014, pirfenidone and nintedanib were approved for the treatment of idiopathic pulmonary fibrosis. Although both drugs reduced the progression of idiopathic pulmonary fibrosis and offered survival benefits, no pharmacologic intervention is strongly recommended for patients with idiopathic pulmonary fibrosis. We conducted a medicinal chemistry-directed search for efficient therapeutic strategies and discovered AK106-001616 [3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)-phenyl]-propionic acid], a novel selective cPLA2 inhibitor. Herein, we describe the preclinical pharmacology of AK106-001616. We believe that readers of The Journal of Pharmacology and Experimental Therapeutics will be interested in this manuscript because our data demonstrate that oral AK106-001616 may provide valuable effects for wide indications without attendant gastrointestinal and cardiovascular risks.

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Treating chronic migraine in CADASIL with calcitonin gene-related peptide receptor antagonism.

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Colorectal Lymphoma: A Contemporary Case Series.

Colon and rectal lymphomas are rare and can occur in the context of posttransplant lymphoproliferative disorder. Evidence-based management guidelines are lacking.

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