Rejected

Neurofibromatosis (NF) is a genetic disorder, and neurofibromatosis types 1 and 2 have different genetic and clinical features. Herein, we present the clinical and genetic aspects of a patient carrying a constitutional NF1 gene mutation and whose neurocutaneous manifestations suggested a NF type 2 (NF2).

Dexmedetomidine, a selective alpha agonist, is traditionally used briefly for perioperative anesthesia and sedation of mechanically ventilated patients. Reports of its use in patients with opioid-induced hyperalgesia and intractable pain and delirium suggested it for patients who otherwise may have required palliative sedation to relieve suffering. We present the protocol developed by the interdisciplinary team in our intensive palliative care unit that allows for safe titrated administration without required vital sign monitoring outside the intensive care unit (ICU) (Supplementary Appendix SA1). We describe its efficacy in eight patients who were receiving comfort-focused care.

Fibromyalgia and post-traumatic stress : role of psychotropic drugs and psychotherapies. The literature shows a high frequency of post-traumatic stress disorder (PTSD) in fibromyalgia syndrome and unexplained chronic pain as a comorbidity of PTSD. On the therapeutic level, the care of patients must be done in the benevolence and respect for the suffering of the patient with a therapeutic education for an adapted nutrition, the maintenance of the maximum possible physical activity and a drug management, physiotherapy and psychotherapy such as behavioral and cognitive therapy and hypnosis. Early diagnostic and therapeutic management require good multidisciplinary coordination for the management of patients suffering from fibromyalgia.

Skin graft donor site pain significantly affects pain management, narcotic use, and hospital length of stay. This study is intended to evaluate the efficacy of regional anesthesia in the burn population to decrease narcotic consumption and to assess the impact on hospitalization costs.

In a heterogenous group of patients with acute headache it is important to diagnose subarachnoid hemorrhage (SAH), a potentially lethal but treatable condition, with short turnaround time and high precision. Spectrophotometry of cerebrospinal fluid (CSF) is an essential part in the investigation of patients with suspected SAH but the analysis is slow and operator dependent.

Chronic gastritis is a common histologic finding in children with functional dyspepsia (FD). While Th17 cells have been implicated in other forms of gastritis, they have not been evaluated in chronic gastritis.

Chronic posterior dislocation is a very rare injury. Various methods have been described for its treatment. This report describes a rare case of post-traumatic chronic posterior dislocation of the shoulder. Posterior bone block procedure performed through a limited posterior deltoid splitting approach was used with good surgical outcomes. The bone block procedure for chronic posterior dislocation is rarely described in the literature.

Progressive familial intrahepatic cholestasis (PFIC) is a rare genetic autosomal recessive disease caused by mutations in , or . Mutational analysis of these genes is a reliable approach to identify the disorder.