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Other primary headaches: Distinct clinical features and uncertain pathophysiology.

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Efficacy, safety and indirect comparisons of lasmiditan, rimegepant, and ubrogepant for the acute treatment of migraine: A systematic review and network meta-analysis of the literature.

We performed a random-effects network meta-analysis to study the efficacy and safety of newly developed drugs for the acute treatment of migraine attacks.

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Update on headaches associated with physical exertion.

Headaches associated with physical exertion include headache precipitated by coughing or other Valsalva maneuvers, headache brought on by prolonged physical exercise, sexual headaches and cardiac cephalalgia.

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Mas-Related G Protein-Coupled Receptors in Gastrointestinal Dysfunction and Inflammatory Bowel Disease: A Review.

Inflammatory bowel disease (IBD) is a chronic debilitating condition, hallmarked by persistent inflammation in the gastrointestinal tract. Despite recent advances in clinical treatments, the aetiology of IBD is unknown and […]

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Videoconferencing of Movement-Based and Psychologically Informed Interventions for Chronic Pain: A Systematic Review and Horizon Scan.

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Safety and tolerability of monoclonal antibodies targeting the CGRP pathway and gepants in migraine prevention: A systematic review and network meta-analysis.

Direct comparisons of the tolerability and safety of migraine preventive treatments targeting the calcitonin gene-related peptide pathway are lacking. This study aimed to compare the safety and tolerability of anti-calcitonin […]

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Update on primary headache associated with sexual activity and primary thunderclap headache.

This narrative review aims to provide an update on primary headache associated with sexual activity and primary thunderclap headache.

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New migraine drugs.

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Positive Allosteric Modulators of Glycine Receptors and Their Potential Use in Pain Therapies.

Glycine receptors are ligand-gated ion channels that mediate synaptic inhibition throughout the mammalian spinal cord, brainstem, and higher brain regions. They have recently emerged as promising targets for novel pain […]

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The Three W’s of Acetaminophen In Children: Who, Why, and Which Administration Mode.

Acetaminophen is one of the oldest medications commonly administered in children. Its efficacy in treating fever and pain is well accepted among clinicians. However, the available evidence supporting the use […]

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