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Exploring the relationship between gratitude and depression among older adults with chronic low back pain: a sequential mediation analysis.

Gratitude has been identified as a key factor in a number of positive health-related outcomes; however, the mechanisms whereby gratitude is associated with well-being among older adults with chronic pain […]

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Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities.

Closely associated with aging and age-related disorders, cellular senescence (CS) is the inability of cells to proliferate due to accumulated unrepaired cellular damage and irreversible cell cycle arrest. Senescent cells […]

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Risk factors for the long-term incidence and progression of knee osteoarthritis in older adults: role of nonsurgical injury.

For one of the most chronic medical conditions, osteoarthritis, uncertainties remain on the impact of injury chronology, the role of repeat injury on the incidence/progression of this disease and the […]

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Molecular and Cellular Mechanisms of Neuropathic Pain in Aging.

Neuropathic pain is a chronic condition that tends to worsen over time, leading to a significant decline in patients’ quality of life. The elderly population is disproportionately affected by this […]

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Age-associated changes in knee osteoarthritis, pain-related behaviors, and dorsal root ganglia immunophenotyping of male and female mice.

Osteoarthritis (OA) is a leading cause of chronic pain, yet OA pain management remains poor. Age is the strongest predictor of OA development, and mechanisms driving OA pain are unclear. […]

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The mechanisms and functions of IL-1β in intervertebral disc degeneration.

Intervertebral disc degeneration (IDD) is the leading cause of low back pain (LBP) and disability in the elderly, imposing significant public health and economic burden worldwide. Meanwhile, the pathological mechanisms […]

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Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain.

Chronic pain is one of the leading causes of disability that may accelerate biological aging and reduce physical function. Epigenetic clocks provide an estimate of how the system ages and […]

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Serum metabolomic profiling identifies potential biomarkers in arthritis in older adults: an exploratory study.

Seronegative elderly-onset rheumatoid arthritis (EORA) and polymyalgia rheumatica (PMR) have similar clinical characteristics making them difficult to distinguish based on clinical features. We hypothesized that the study of serum metabolome […]

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Identification of five hub immune genes and characterization of two immune subtypes of osteoarthritis.

Osteoarthritis (OA) is one of the most prevalent chronic diseases, leading to degeneration of joints, chronic pain, and disability in the elderly. Little is known about the role of immune-related […]

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Factors Associated with Low Inter-Session Reliability of Conditioned Pain Modulation in Older People with or Without Chronic Musculoskeletal Pain.

Conditioned pain modulation (CPM) is a measurement of the descending pain pathways that inhibit or facilitate afferent noxious stimuli. The reliability of CPM in older individuals with or without chronic […]

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