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Hypothetical framework for post-COVID 19 condition based on a fibromyalgia pathogenetic model.

There is a clear clinical overlap between fibromyalgia, myalgic encephalomyelitis, and post-COVID 19 condition. Chronic fatigue, cognitive impairment, and widespread pain characterize these 3 syndromes. A steady line of investigation […]

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Perspective on salutogenic approaches to persistent pain with a focus on mindfulness interventions.

In this article, we provide a unique perspective on the use of mindfulness interventions in a whole health framework embedded within the theory of salutogenesis and the concept of painogenic […]

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Searching for the rainbow: biomarkers relevant for chronic postsurgical pain.

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NICE recommends rimegepant for treating acute migraine in adults.

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Device profile of the Evoke Physiologic Closed-loop spinal cord stimulation system for the treatment of chronic intractable pain: overview of its safety and efficacy.

The Evoke® spinal cord stimulation (SCS) device enables the closed-loop feedback of dynamically measured evoked compound action potentials (ECAPs) to adjust stimulation amplitude for every stimulation pulse to maintain the […]

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TRPV1 and TRPA1 channels interact to mediate cold hyperalgesia in mice.

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Mechanisms inherent in acute-to-chronic pain after surgery – risk, diagnostic, predictive, and prognostic factors.

Acute pain is an expected consequence of a surgery, but it is far from being well controlled, due to its complex bio-psycho-social nature. One major complication of acute pain is […]

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A revitalized biopsychosocial model: core theory, research paradigms, and clinical implications.

The biopsychosocial model (BPSM) was proposed by George Engel in 1977 as an improvement to the biomedical model (BMM), to take account of psychological and social as well as biological […]

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Both patients and the public should be involved in setting the pain research agenda.

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Na1.7: A central role in pain.

Loss of function of sodium channel Na1.7 produces pain insensitivity. In this issue, Deng et al. show that analgesia after Na1.7 removal or pharmacological blockade is not driven by enkephalin overexpression. […]

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