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Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain.

Chronic pain is one of the leading causes of disability that may accelerate biological aging and reduce physical function. Epigenetic clocks provide an estimate of how the system ages and […]

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New daily persistent headache: A systematic review and meta-analysis.

To perform a systematic review and meta-analysis of the epidemiology, precipitants, phenotype, comorbidities, pathophysiology, treatment, and prognosis of primary new daily persistent headache.

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Migraine symptoms, healthcare resources utilization and disease burden in a large Polish migraine cohort : Results from ‘Migraine in Poland’-a nationwide cross-sectional survey.

The Migraine in Poland study is the first large scale nationwide cross-sectional online survey of symptoms, approaches to management, treatment patterns, quality of life, and sociodemographic characteristics of the Polish […]

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Suffering out of sight but not out of mind – interpreting experiences of sick leave due to chronic pain in a community setting: a qualitative study.

Chronic pain is a complex health problem affecting about one-fifth of the European population. It is a leading cause of years lived with disability worldwide, with serious personal, relational and […]

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Prevalence and risk factors of depressive symptoms in children and adolescents with juvenile idiopathic arthritis.

Depression is a serious disorder disproportionately affecting people with chronic diseases, yet, to date is rarely recognized comorbidity in pediatric rheumatology clinical routine care. The aim of this study was […]

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Trends in Pain Medication Use in Patients With Type 2 Diabetes: NHANES 2005-2018.

The aim of this research was to compare pain medication use trends among adults with and without type 2 diabetes in the US. This cross-sectional study used data of adults […]

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Association of periodontal disease with migraine: A large-scale community-based cross-sectional study.

Periodontal disease may drive a systemic inflammatory response that triggers migraine; however, the association between periodontal disease and migraine has rarely been investigated in a community-based setting.

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The plasma fibrinogen levels in the nitroglycerin-induced chronic migraine rat model and its association between migraine-associated vestibular dysfunction.

The purpose of this study was to measure the vestibular function and plasma fibrinogen level in the nitroglycerin (NTG)-induced chronic migraine rats, and explore the effect of defibrinogenation on migraine […]

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IL-17 inhibitor-associated inflammatory bowel disease: A study based on literature and database analysis.

Few real-world studies have shown clear association between interleukin (IL)-17 inhibitors and inflammatory bowel disease (IBD) onset. This study investigated the reporting prevalence and evaluated the clinical features and management […]

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Treatment with delgocitinib cream improves itch, pain and other signs and symptoms of chronic hand eczema: Results from the Hand Eczema Symptom Diary in a phase IIb randomized clinical trial.

Measuring patient-reported outcomes is crucial to fully capture the burden of chronic hand eczema (CHE).

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