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A revitalized biopsychosocial model: core theory, research paradigms, and clinical implications.

The biopsychosocial model (BPSM) was proposed by George Engel in 1977 as an improvement to the biomedical model (BMM), to take account of psychological and social as well as biological […]

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Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021.

Osteoarthritis is the most common form of arthritis in adults, characterised by chronic pain and loss of mobility. Osteoarthritis most frequently occurs after age 40 years and prevalence increases steeply […]

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Does active inference provide a comprehensive theory of placebo analgesia?

Placebo interventions generate mismatches between expected pain and sensory signals from which pain states are inferred. Since we lack direct access to bodily states, we can only infer whether nociceptive […]

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Systemic treatments for atopic dermatitis (eczema): systematic review and network meta-analysis of randomized trials.

Atopic dermatitis (AD) is an inflammatory skin condition with multiple systemic treatments and uncertainty regarding their comparative impact on AD outcomes.

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Topical treatments for atopic dermatitis (eczema): systematic review and network meta-analysis of randomized trials.

Atopic dermatitis (AD) is a common skin condition with multiple topical treatment options, but uncertain comparative effects.

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Bodily maps of emotions and pain: tactile and hedonic sensitivity in healthy controls and patients experiencing chronic pain.

Pain is an unpleasant sensory and emotional experience. Both pain and emotions are warning signals against outside harm. Interoception, bodily sensations of emotions can be assessed with the emBODY tool […]

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Virtual Reality Distraction for Reducing Acute Postoperative Pain After Hip Arthroplasty: A Randomized Trial.

Relaxation and distraction provided by virtual reality presentations might be analgesic and reduce the need for opioid analgesia. We tested the hypothesis that a virtual reality program (AppliedVR) decreases acute […]

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Pain experience in eating disorders: The mediating role of depression, alexithymia and interoceptive awareness.

Evidence suggests reduced sensitivity to pain due to high pain threshold in anorexia and bulimia nervosa and a possible role of depression, alexithymia and interoceptive awareness on pain experience. This […]

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Which headache disorders can be diagnosed concurrently? An analysis of ICHD3 criteria using prime encoding system.

Real-life headache presentations may fit more than one ICHD3 diagnosis. This project seeks to exhaustively list all logically consistent “co-diagnoses” according to the ICHD3 criteria. We limited our project to […]

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Electroacupuncture alleviates the relapse of pain-related aversive memory by activating KOR and inhibiting GABAergic neurons in the insular cortex.

Pain-related aversive memory is common in chronic pain patients. Electroacupuncture has been demonstrated to block pain-related aversive memory. The insular cortex is a key region closely related to aversive behaviors. […]

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