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Neuropathic Pain

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Effect of transauricular nerve stimulation on perioperative pain: a single-blind, analyser-masked, randomised controlled trial.

Activation of central autonomic pathways, including those regulating the arterial baroreflex, might reduce acute pain. We tested the hypothesis that transcutaneous auricular nerve stimulation (TAN) reduces pain after orthopaedic trauma […]

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Comparative transcriptome of dorsal root ganglia reveals distinct etiologies of paclitaxel- and oxaliplatin-induced peripheral neuropathy in rats.

Chemotherapy-induced peripheral neuropathy is one of the most common side effects of anticancer therapy. It is anticipated that chemotherapies with different mechanisms of action may affect somatosensory neurons differently. This […]

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Corticomotor excitability is altered in central neuropathic pain compared with non-neuropathic pain or pain-free patients.

Central neuropathic pain (CNP) is associated with altered corticomotor excitability (CE), which can potentially provide insights into its mechanisms. The objective of this study is to describe the CE changes […]

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Bibliometric analysis of research articles on post-herpetic neuralgia published from 1991 to 2020.

Post-herpetic neuralgia (PHN) is one of the most painful diseases, which has made it a major concern for pain physicians. We aimed to quantitatively analyze the research outputs of studies […]

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Chrysin loaded nanovesicles ameliorated diabetic peripheral neuropathy. Role of NGF/AKT/GSK-3β pathway.

Diabetic peripheral neuropathy (DPN) is a common diabetic complication. Chrysin (CHY) has many biological properties but poor oral bioavailability. This study investigates the effect of CHY and CHY-loaded nanovesicles (CHY-NVs) […]

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The blood proteomic signature of prurigo nodularis (PN) reveals distinct inflammatory and neuropathic endotypes: a cluster analysis.

Prurigo nodularis (PN) is an extremely pruritic, chronic inflammatory skin disease. Little is known about systemic inflammation in PN.

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Insular cortex stimulation alleviates neuropathic pain via ERK phosphorylation in neurons.

The clinical use of brain stimulation is attractive for patients who have side effects or tolerance. However, studies on insular cortex (IC) stimulation are lacking in neuropathic pain. The present […]

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A randomised controlled trial for the effectiveness of an audiovisual device on anxiety and pain perception during a nerve block for chronic pain relief.

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Metabotropic glutamate receptor 5-mediated inhibition of inward-rectifying K channel 4.1 contributes to orofacial ectopic mechanical allodynia following inferior alveolar nerve transection in male mice.

Inward-rectifying K channel 4.1 (Kir4.1), which regulates the electrophysiological properties of neurons and glia by affecting K homeostasis, plays a critical role in neuropathic pain. Metabotropic glutamate receptor 5 (mGluR5) […]

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Chemical Neurolysis of the Genicular Nerves for Chronic Refractory Knee Pain: an Observational Cohort Study.

Evaluate outcomes of genicular nerve chemical neurolysis (GChN) in a real-world population with chronic knee pain.

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