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Targeting Nociceptive Neurons and Transient Receptor Potential Channels for the Treatment of Migraine.

Migraine is a neurovascular disorder that affects approximately 12% of the global population. While its exact causes are still being studied, researchers believe that nociceptive neurons in the trigeminal ganglia […]

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Corneal confocal microscopy identifies corneal nerve fiber loss in patients with migraine.

Migraine affects >1 billion people but its pathophysiology remains poorly understood. Alterations in the trigeminovascular system play an important role. We have compared corneal nerve morphology in patients with migraine […]

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Idealized multiple-timescale model of cortical spreading depolarization initiation and pre-epileptic hyperexcitability caused by Na1.1/SCN1A mutations.

Na1.1 (SCN1A) is a voltage-gated sodium channel mainly expressed in GABAergic neurons. Loss of function mutations of Na1.1 lead to epileptic disorders, while gain of function mutations cause a migraine […]

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The role of artificial intelligence in headache medicine: Potential and peril.

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Characterizing opioid use in a Dutch cohort with migraine.

There is lack of data on opioid (over)use for migraine in Europe.

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Questionnaire and structural imaging data accurately predict headache improvement in patients with acute post-traumatic headache attributed to mild traumatic brain injury.

Our prior work demonstrated that questionnaires assessing psychosocial symptoms have utility for predicting improvement in patients with acute post-traumatic headache following mild traumatic brain injury. In this cohort study, we […]

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Targeting the intrinsically photosensitive retinal ganglion cell to reduce headache pain and light sensitivity in migraine: A randomized double-blind trial.

Approximately 80% of patients with migraine report light sensitivity during attacks and almost half report that following headache, light sensitivity is the most bothersome symptom. Light wavelengths stimulating intrinsically photosensitive […]

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Microvascular involvement in migraine: an optical coherence tomography angiography study.

The aim of this study was to evaluate the microvasculature of the macula and the optic nerve in patients affected by migraine with aura (MA) and without aura (MO) by […]

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Early maladaptive schemas in episodic and chronic migraine in adolescents.

Psychotherapies, such as schema therapy, are receiving increasing attention in the management of pediatric headaches. The purpose of this study was to investigate early maladaptive schemas (EMSs) in adolescents with […]

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Global trends in research on cervicogenic headache: a bibliometric analysis.

There has been a marked increase in cervicogenic headaches in recent years, significantly affecting sufferers’ daily lives and work. While several treatments exist for this type of headache, their long-term […]

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