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There is a major unmet need to develop new therapies for migraine. We have previously demonstrated the therapeutic potential of the acid sensing ion channel (ASIC) blockade in migraine, via an ASIC1 mechanism. ASIC3 is expressed in the trigeminal ganglion and its response is potentiated by nitric oxide that can trigger migraine attacks in patients, and thus we sought to explore the potential therapeutic effect of ASIC3 blockade in migraine.
Learn More >This article reviews current headache disability measures and clinical need, as well as presenting the rationale for a new measure addressing work-related disability in migraine patients and the steps devoted to this aim.
Learn More >This proposed systematic review will identify the existing evidence on medication-overuse headache in children and adolescents.
Learn More >To compare the prevalence of facial pain and headache across various regions in Sweden.
Learn More >Ubrogepant is an oral, small-molecule calcitonin gene-related peptide receptor antagonist for acute migraine treatment.
Learn More >We aimed to evaluate associations of human leukocyte antigen variants with migraine or headache in hospital and population-based settings.
Learn More >In countries like India, many migraine patients presenting to primary care clinics fail to fulfill standard (ICHD 3) migraine diagnostic criteria. Since they do not present with typical ICHD 3 migraine diagnostic symptoms, it is necessary to define the criteria for atypical migraine. This would ensure that the patients receive the right treatment approach, both non-pharmacological and pharmacological. Looking for triggers, family history, activity affected and absolute normality in between attacks, past episodes of episodic syndromes, prodromal and oculonasal autonomic symptoms will help in identifying the migraine origin of these headaches.
Learn More >To determine the relationship between hormonal contraceptive (HC) use and painful symptoms, particularly those associated with headache and painful temporomandibular disorders (TMD).
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