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Burden of headache disorders in China, 1990-2017: findings from the Global Burden of Disease Study 2017.

Headache has emerged as a global public health concern. However, little is known about the burden from headache disorders in China. The aim of this work was to quantify the spatial patterns and temporal trends of burden from headache disorders in China.

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Cluster headache: an overview of established and emerging treatments.

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Trigeminal Autonomic Cephalalgias.

The trigeminal autonomic cephalalgias (TACs) are a group of primary headache syndromes all marked by unilateral headache and ipsilateral cranial autonomic features. The TACs include cluster headache, paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing, and hemicrania continua. Pathophysiology includes the trigeminal pain system, autonomic system, hypothalamus, and more recently an identified role for the vagus nerve. Diagnosis is made after looking at headache frequency, duration, and accompanying symptoms. Each TAC has its own unique treatment, which is discussed in depth.

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Cortical Hyper-Excitability in Migraine in Response to Chromatic Patterns.

Individuals with migraine exhibit heightened sensitivity to visual input that continues beyond their migraine episodes. However, the contribution of color to visual sensitivity, and how it relates to neural activity, has largely been unexplored in these individuals.

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Early Onset of Efficacy With Fremanezumab for the Preventive Treatment of Chronic Migraine.

To assess the onset of efficacy for fremanezumab in chronic migraine by evaluating pain-related clinical measures at different time points.

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Current understanding of premonitory networks in migraine: A window to attack generation.

To describe neuronal networks underlying commonly reported migraine premonitory symptoms and to discuss how these might precipitate migraine pain.

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Migraine in Women.

Migraine is a lifelong condition that disproportionately affects women and, if not effectively managed, can lead to significant disability. It is important for clinicians to have a good understanding of the impact of the hormonal fluctuations that occur throughout a female migraineur's life, so that appropriate, stratified therapies can be implemented. In doing so, whether it is migraine onset at menarche in an adolescent young woman, or migraine worsening in a perimenopausal female migraineur, quality of life can be ensured.

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OnabotulinumtoxinA Wear-off Phenomenon in the Treatment of Chronic Migraine.

To evaluate the frequency and features of onabotulinumtoxinA (onabotA) wear-off in chronic migraine (CM).

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Grey matter changes in patients with vestibular migraine.

To identify structural changes in the brain regions of patients with vestibular migraine (VM) so as to better understand its pathophysiology.

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A Randomized Phase 2 Study of Erenumab for the Prevention of Episodic Migraine in Japanese Adults.

A phase 2, double-blind, placebo-controlled study to evaluate the efficacy and safety of erenumab for the prevention of episodic migraine in Japanese patients was conducted.

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