Papers: 8 Mar 2025 - 14 Mar 2025

Pain independent of disease activity is frequently reported by rheumatoid arthritis patients and remains undertreated. Preclinical evidence suggests that imbalance of neuroimmune proresolving interactions within dorsal root ganglia (DRG) rather […]

A subset of peripheral sensory neurons expressing specific Mas-related G-protein-coupled receptors and transient receptor potential channels mediate pruritogen-induced chemical itch. However, the molecular mechanisms that regulate the excitability of these […]

The human brain has a remarkable ability to learn and update its beliefs about the world. Here, we investigate how thermosensory learning shapes our subjective experience of temperature and the […]

Pain relief is the most frequently reported motivation for opioid misuse, but it remains unclear how pain alters reward pathway function contributing to maladaptive opioid use and whether these neuroadaptations […]

Psoriatic arthritis (PsA) is anatomically much more heterogeneous than rheumatoid arthritis, as, beyond synovitis, it often also involves enthesitis, peritendinitis, tenosynovitis, osteitis and periostitis. This heterogeneity currently precludes a gold […]

Raised intracranial pressure (ICP) is associated with altered cerebral hemodynamics and cephalic pain. The relationship between the algetic response and cortical neurovascular changes in raised ICP is unclear. This study […]

Chronic pain is common and debilitating, yet is inadequately treated by current therapies, which can have life-threatening side effects. Treatments targeting G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs), […]

The value of engaging people with lived experience into chronic pain research is becoming increasingly recognized, yet the perspectives of individuals with chronic pain who have not previously participated in […]

Itch is an unpleasant sensation that is encoded by specific sensory neurons called pruriceptors. Itch is associated with almost all skin diseases. Recent studies revealed that many itchy skin diseases […]

In recent years, headache diseases have spread throughout the world, causing great suffering and even severe disability to patients, and increasing the burden on health care systems. However, studies of […]

Postoperative abdominal adhesions are the leading cause of bowel obstruction and a cause of chronic pain and infertility. Adhesion formation occurs after 50 to 90% of abdominal operations and has […]

Multiple sensory afferents, including mechanosensitive and nociceptive nerves, are projected to the periodontium. Peptidergic afferents expressing transient receptor potential vanilloid 1 (TRPV1), a receptor for capsaicin, mediate pain caused by […]

Neuropathic pain involves complex cortical mechanisms, yet the role of the medial secondary visual cortex (V2M) remains poorly understood. We hypothesized that glutamatergic neurons in V2M (V2M) contribute to pain […]

Depression and anxiety are common among adults with chronic pain, but their prevalence is unclear.

Diabetes mellitus affects more than half a billion people globally, often leading to painful diabetic neuropathy (PDN). Spinal cord stimulation (SCS) has emerged as a promising treatment for PDN.

Mature adults often exhibit higher pain thresholds than younger individuals. However, this phenomenon is poorly understood, especially with regards to peripheral nervous system signaling.

Multifunctional bionic devices have widespread applications in neuromorphic computing, intelligent sensors, and robotics. The inherent properties of memristors make them suitable for these emerging applications, but different applications require either […]

To examine the most common patterns of pain and symptom management strategies among adults living with cerebral palsy (CP), and to determine if there are differences by pain phenotype or […]

Antidepressants are commonly used to treat low back pain and spine-related leg pain. However, their benefits and harms are uncertain. This is an update of a 2008 Cochrane review of […]

The opioid overdose crisis had progressed broadly in the United States, with an 21% increase from 2016 to 2017, and specifically in Massachusetts, with a peak rate of 1,374 deaths […]

Virtual reality (VR) can be analgesic through intercortical modulation. This study investigated neural activities and correlates during different interactive modes.

Existing evidence supports a correlation between multi-site chronic pain and post-traumatic stress disorder (PTSD), but it is yet to be determined if this correlation is causal and in what direction […]

Persistent physical and psychological stress is highly relevant to the development of chronic muscle pain; however, the neural mechanisms underlying stress-induced hyperalgesia remain largely unknown. This study aimed to elucidate […]

The purpose of this study was to identify molecular subtypes and hub genes in fibromyalgia [FM] based on immune-related genes [IRGs].

The mechanisms underlying Rheumatoid Arthritis (RA) remain unclear. Despite having relatively well-defined treatment strategies, current therapeutic approaches only achieve a remission rate of 70 %-80 %, with poor prognosis and no clear […]

The trial-to-implant ratio for spinal cord stimulation (SCS) has long served as a cornerstone metric for optimizing patient selection and cost containment. Historically, screening trials played a pivotal role in […]

Spinal cord injury (SCI) causes persistent motor, sensory, psychological, and bladder dysfunctions, with clinical evidence indicating better recovery in females compared to males. However, the mechanisms driving these sex-specific differences […]

Chemotherapy-induced peripheral neuropathy (CIPN) severely diminishes the quality of life for cancer survivors, yet effective treatments remain scarce. Esketamine, a commonly used anesthetic, has demonstrated neuroprotective effects by restoring gut […]

Morphine and other synthetic opioids are widely prescribed to treat pain. Prolonged morphine exposure can paradoxically enhance pain sensitivity in humans and nociceptive behavior in rodents. To better understand the […]

Previous investigations on pain modulatory effects of the rubber hand illusion (RHI) yielded mixed results. However, these studies used separate stimuli to induce pain and the RHI. Using a visual-thermal […]

Low Back Pain (LBP) is the most prevalent musculoskeletal condition worldwide and a leading cause of disability, significantly affecting mobility, work productivity, and overall quality of life. Due to its […]

The mechanism behind masseter muscle pain, a major symptom of temporomandibular disorder (TMD), has remained poorly understood. Previous report indicates that adenosine triphosphate (ATP) in involved in the masseter muscle […]

Chronic pain due to lumbar disc herniation (LDH) significantly impairs quality of life and is often accompanied by emotional disturbances, such as anxiety and depression. Despite the recognition of these […]

The present work aimed to load propranolol hydrochloride (PN), a beta-blocking agent with low oral bioavailability, into PLGA-lipid hybrid nanoparticles (PLHNPs) for augmenting its efficacy. PLHNPs contain phospholipid (PC) in […]

Migraine with aura is a common neurological disorder. Cortical spreading depression is the hypothetical pathophysiologic correlate, but it has never been directly recorded during migraine in a human. A 32-year-old […]

Type 2 inflammation has a major role in barrier tissues such as the skin and airways and underlies common conditions including atopic dermatitis (AD) and asthma. Cytokines including interleukin 4 […]

Central sensitization plays a critical role in bladder pain syndrome/interstitial cystitis (BPS/IC). Electroacupuncture (EA) nerve stimulation therapy has been broadly acknowledged as an effective means of alleviating chronic pathological pain. […]

Recent evidence suggests that the rapid-acting antidepressant ketamine has immune regulatory functions. The complement system is an important component of the innate immune response and plays a key role in […]

Chronic pain presents as a complex condition encompassing sensory (Zhang Z et al. Cell Rep 12;752-759, 2015) and emotional components, often accompanied by anxiety, depression, insomnia, and cognitive impairment. These factors […]

The Slack channels, encoded by KCNT1, are found in neurons across the central nervous system (CNS) and peripheral nervous system (PNS), generating a delayed outward current known as sodium-activated potassium […]

The severity and impact of pain can vary greatly, even in individuals with the same physical injury. This variation underscores the need for a variety of treatment strategies in effective […]

The offset analgesia phenomenon refers to the disproportionately large decrease in the perceived pain following a slight decrease in intensity of a noxious heat stimulus. It is considered an expression […]

Pain management in pregnant and postpartum people with an opioid use disorder requires a balance among the risks associated with opioid tolerance, including withdrawal or return to opioid use, considerations […]

Chronic pain is a significant public health concern that diminishes patients’ quality of life and imposes considerable socioeconomic costs. Effective pharmacological treatments for ongoing pain are limited. Recent studies have […]

Vincristine (VCR) is a commonly used clinical anti-cancer drug, but it can also induce neurotoxicity and cause vincristine-induced neuropathic pain (VINP). The metabotropic glutamate receptor 5 (mGluR5) within spinal dorsal […]

Introduction Evoked compound action potentials (ECAPs) during spinal cord stimulation (SCS) may be useful in the treatment of chronic pain as a control signal for closed-loop neuromodulation. However, considerable inter-individual […]

Diabetic nephropathy is a severe chronic complication characterized by cytotoxicity, inflammation, and fibrosis, ultimately leading to renal failure. This study systematically investigated the effects of the PARP1 inhibitor PJ-34 on […]

Osteoarthritis (OA) is the most common musculoskeletal disease globally and is the main reason for the chronic pain and disability in people over sixty-five worldwide. Degradation of the articular cartilage, […]

A significant portion of adolescents suffer from mental illnesses and persistent pain due to repeated stress. The components of the nervous system that link stress and pain in early life […]

Chronic prostatitis/chronic pelvic pain syndrome (CPPS/CP) is a prevalent urinary disorder primarily characterized by pelvic pain and discomfort, bladder dysfunction, and sexual dysfunction. Currently, there is no effective method to […]

Neuropathic pain is a complex condition resulting from damage or disease in the somatosensory nervous system, causing significant physical and emotional distress. Despite its profound impact, the underlying causes and […]

Itch is a debilitating symptom that affects ∼40% of the population and significantly impacts patients’ quality of life. The management of chronic itch remains a significant challenge due to the […]

The burden of migraine in Mexican Emergency Department (ED) settings remains understudied. This study aimed to determine the frequency of migraine-related ED visits within the ED Mexican Ministry of Health’s […]

Effective prevention and management strategies for chronic pain remain elusive. This has prompted investigations into biomarkers to better understand the mechanisms underlying pain development and persistence. One promising marker is […]

Sensory signals generated by peripheral nociceptors are transmitted by peptidergic and nonpeptidergic nociceptive primary afferents to the superficial spinal dorsal horn, where their central axon terminals establish synaptic contacts with […]

Diabetic neuropathy (DN) is characterized by nerve damage as a consequence of diabetes mellitus. Diabetes causes high blood glucose and triglyceride levels, which destroy the nerve blood vessels over time […]

The biopsychosocial model suggests that temporomandibular disorders (TMDs) often coexist with mental health disorders, particularly depression and anxiety, affecting a significant portion of the global population. The interplay between TMDs […]

This study aimed to characterize pain intensity (average, worst) and disease severity in youth with inflammatory bowel disease in the 12-months post-diagnosis, and to examine the relation between pain and […]

While it is well known that the sensory arm of the micturition reflex is mediated by A-δ afferents in the pelvic nerve, the urinary bladder is also innervated by afferents […]

Chronic pain is a prevalent condition in companion animals and poses significant welfare challenges. To address these concerns effectively, veterinary clinicians must have a comprehensive understanding of the neuroanatomy of […]

This research aims to better delineate how intrathecal drug delivery systems (IDDS) are incorporated into the oncology care continuum and highlight the need for further awareness of interventional options for […]

Chronic pain affects approximately 30% of the global population, posing a significant public health challenge. Despite their widespread use, traditional pharmacological treatments, such as opioids and NSAIDs, often fail to […]

This study investigates the association between diabetes and chronic pain across various body regions in individuals aged 50 years and older, while assessing the influence of gender, hypertension status, age, and […]

The trends of recreational use of cannabis and the use of cannabis for medical indications (i.e., “medical cannabis”) have grown in recent years. Despite that, there is still limited scientific […]

The primary aim of this study was to examine the way in which parent stress, including adverse childhood experiences (ACEs) and emotional distress, pain, and resilience, relates to child pain […]

Several countries have participated in WHO COPCORD. The Global Disease Burden program (GBD) reports selected MSK disorders. We used a COPCORD India protocol to estimate the national burden of MSK […]

This brief narrative review discusses the clinical manifestations, diagnosis, and management of trigeminal nerve-related conditions, such as neuropathy and neuralgia, in patients with diabetes mellitus (DM). Although these conditions are […]

This study aimed to evaluate levels of fecal calprotectin (FC), a biomarker that helps distinguish irritable bowel syndrome from inflammatory gut disorders, in patients with fibromyalgia syndrome (FMS) and compare […]

While the Lenke classification enhances our structural understanding of adolescent idiopathic scoliosis (AIS), the biomechanical implications for spinal range of motion (ROM) and intervertebral disc (IVD) loadings remain unclear. This […]

Tendinopathies are a significant global health issue due to their detrimental effects on mobility and quality of life. Pharmacological treatments, although widely used for pain management, often demonstrate limited efficacy. […]

Herpes simplex virus (HSV) infections of the central nervous system (CNS) are associated with high morbidity and mortality. Prompt recognition and antiviral treatment are critical to improve patient outcomes. This […]

Migraine and cluster headache are two primary headache disorders for which conventional treatments are limited. Classic psychedelic substances such as lysergic acid diethylamide (LSD) and psilocybin are potentially promising new […]

In the context of the opioid epidemic, it is indispensable to reduce the use of opioids and develop new therapeutic alternatives. The combined use of ketamine, lidocaine and dexmedetomidine has […]

Chronic pain is a prevalent comorbidity among those with posttraumatic stress disorder (PTSD). Chronic pain can be divided into specific pain (i.e., involving a single body system) and complex pain […]

To explore the convergent validity of 12-item World Health Organization Disability Assessment Schedule (WHODAS 2.0) comparing it to Neck Disability Index (NDI).

To investigate the relationship between leptin levels, insulin resistance (measured by HOMA), and clinical outcomes related to pain, disability, and shoulder range of motion (ROM) in patients with frozen shoulder […]

In China, the drug treatment of many cancer pain patients is obviously affected by people’s lack of knowledge and confidence, and cancer pain symptoms fail to be effectively controlled. This […]

The subjective nature of pain complicates objective verification, often leading to noncredible symptom reports in compensable settings. Across two studies, we evaluated the Italian Self-Report Symptom Inventory (SRSI-It) in distinguishing […]

The aim of this study was to compare individuals with chronic pain who were cannabis nonusers and those at low, moderate, and high cannabis use disorder (CUD) risk levels on […]

To investigate the characteristics and nature of headache in a population of patients with acromegaly.

To perform a systematic review and meta-analysis to evaluate the effectiveness of machine learning (ML) algorithms in the diagnosis of vestibular migraine.

This study utilized a longitudinal survey in Japan to investigate whether higher Central Sensitization Inventory (CSI) scores, serving as a proxy for central sensitization-related symptoms, are associated with an increased […]

The pathophysiological mechanism of migraine is still not clear. Thus, this study aimed to evaluate the changes in effective connectivity (EC) in the brain functional network underlying migraine and its […]

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent condition in urology characterized by chronic pain. The pathogenesis of CP/CPPS remains unclear.

Chronic visceral hypersensitivity is associated with an overstressed pain response to noxious stimuli (hyperalgesia). Microbiota are active modulators of host biology and are implicated in the etiology of visceral hypersensitivity.

Migraine is associated with various types of stigma. This study aims to evaluate stigmatizing attitudes towards people with migraine by people without active migraine.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder associated with progressive loss of motor neurons, this result in muscle denervation, atrophy and consequently death takes place due to respiratory […]

Spinal cord injury (SCI) is a serious neurological disorder that causes loss of mobility, pain, and autonomic dysfunction, resulting in altered sensation and devastating loss of function. Current treatments for […]

Neuropathic skeletal injuries in children are common manifestations of conditions associated with sensory impairment. The underlying aetiologies may be rare entities such as congenital insensitivity to pain or more prevalent […]

Bone cancer pain (BCP) is not adequately addressed by current treatment methods, making the exploration of effective management strategies a topic of significant interest. Bone marrow mesenchymal stem cells (BMSCs) […]

Migraine, a severe headache accompanied by nausea, photophobia and phonophobia, can be controlled with pharmacological as well as non-pharmacological therapies. In biofeedback, patients learn to voluntarily modify their bodily reactions […]

Endometriosis is a debilitating condition characterized by the growth of endometrial-like tissue outside the uterus, leading to chronic pain and inflammation. While its etiology remains complex, emerging evidence implicates environmental […]

Chronic pain affects millions worldwide, reducing quality of life and posing a major healthcare challenge. This review aims to explore advancements in neurosurgical interventions for managing chronic pain, focusing on […]

Neuropathic pain is a common and severe type of chronic pain, and its pathogenesis has not been fully defined. Increasing evidence shows that spinal astrocytes play indispensable roles in the […]

Chronic pain is a major cause of suffering. This interferes with daily functioning and is often accompanied by distress. However, current therapeutic strategies for chronic pain are unsatisfactory because of […]

Neuropathic pain (NPP) is caused by damage to the somatosensory nervous system. Its prominent symptoms are spontaneous pain, hyperalgesia and abnormal pain. This pain is long-lasting and unbearable, seriously affecting […]

The purpose of this study was to conduct a bibliometric analysis of the literature on stem cell therapy for osteoarthritis (OA) to visualize recent developments, identify hot spots, and determine […]

Ulcerative colitis is a type of chronic inflammatory bowel disease characterised by abdominal pain, bloody diarrhoea, rectal bleeding and ulcerations in colon. This illness has significant health risks as it […]

Tuberculosis (TB) and chronic pain are global health concerns that affect millions of people, often requiring long-term, effective treatment strategies. The conventional therapies used to manage these conditions come with […]

Mechanical allodynia, the pain caused by innocuous tactile stimuli, is a hallmark symptom of neuropathic pain that is often resistant to currently available treatments. Cannabinoids are widely used for pain […]

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint pain, swelling, and stiffness, affecting approximately 1% of the adult population. Tocilizumab (TCZ), a monoclonal antibody targeting the IL-6 […]

Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects millions of people worldwide and is characterized by persistent inflammation, pain, and joint destruction. In RA, the dysregulation of the […]

To compare the 2017 National Academies of Sciences, Engineering, and Medicine cannabis report to state medical cannabis (MC) laws defining approved qualifying conditions (QC) from 2017 and 2024 and to […]

Observing the effects and roles of acupuncture on the morphology and neural coding damage of central amygdala (CeA) neurons in chronic inflammatory pain with depression (CIPD) mice and exploring the […]

The health disparities experienced by gender-diverse youth have not yet been adequately examined within specific pediatric populations, such as chronic pain. Furthermore, such disparities need to be examined within the […]

Platelet-rich plasma (PRP) is a popular treatment option in managing chronic tendinopathies, although the literature is inconsistent, mainly because of significant heterogeneity in patient populations. Patients who failed conservative management […]

Manual therapy remains an underutilized yet promising complementary intervention for headache management. Despite growing evidence supporting its efficacy, it is often overshadowed by pharmacological approaches and other non-pharmacological treatments such […]

Painful diabetic neuropathy (PDN) is a common complication in patients with type 2 diabetes mellitus (T2DM) with disruption of vitamin D (VD) activity as one of the risk factors. Active […]

Patients with neuropathic pain (NP), caused by injury or disease of the somatosensory nervous system, usually suffer from severe pain. Our previous studies revealed that electroacupuncture (EA) stimulation could effectively […]

The opioid crisis has highlighted the urgent need for alternative pain management strategies. This review explores novel non-opioid targets and pathways involved in pain modulation, highlighting advancements in understanding and […]

Chronic postsurgical pain is recognised increasingly as a complication of caesarean delivery, with implications for a large cohort of patients. As interest in this area has grown, there has been […]

Pigs can suffer from pain due to spontaneously occurring diseases, wounds, injuries, trauma, and physiological conditions such as the farrowing process; however, this pain is often neglected. To increase knowledge […]

Neuropathic pain, a debilitating nerve injury-induced condition, remains a significant clinical challenge. This study evaluates the effect of histone deacetylase 6 (HDAC6) inhibition in a spared nerve injury (SNI) mouse […]

Chronic urticaria (CU) arises from a multifaceted interplay of immunological, neurological, and psychological components. Immune dysregulation, mediated through both immunoglobulin E (IgE)-dependent and IgE-independent pathways, plays a pivotal role in […]

Elucidating how ancestral behavioural traits have been repurposed for psychological and social functions is critical to advancing our understanding of human behavioural evolution. Self-scratching, originally a hygienic response and known […]

Menopause is the natural cessation of ovarian function, typically occurring at a mean age of 52 years in the United States. Vasomotor symptoms (VMS; hot flashes and night sweats) affect […]

Knee osteoarthritis (KOA) is a multifactorial degenerative joint disease influenced by lipid metabolism, systemic inflammation, and dietary factors. This study integrates clinical data, biochemical markers, and machine learning models to […]

Orofacial pain (OFP) includes chronic pain conditions categorized into musculoskeletal (MS), neurovascular (NV), and neuropathic (NP) pain types, encompassing temporomandibular disorders (TMD), migraines, trigeminal neuralgia (TN), post-traumatic neuropathies, and burning […]

Endometriosis is a pathological condition characterized by the presence of the endometrial tissue, outside the uterine cavity. It affects nearly 10% of women of reproductive age and is responsible for […]

Neuropathic pain, a debilitating condition arising from somatosensory system damage, significantly impacts quality of life, leading to anxiety, self-mutilation, and depression. Oxidative and nitrosative stress, an imbalance between reactive oxygen […]

Osteoarthritis (OA) is a common degenerative joint disease that progressively destroys articular cartilage, leading to increased joint friction and severe pain. Therefore, OA can be treated by restoring the lubricating […]

While the modulation of the excitatory and inhibitory neuronal transmission by the phytochemical flavonoid, myricetin (MYR), has been noted in the nervous system, the way in which MYR affects the […]

Patients with Complex Regional Pain Syndrome (CRPS) present prolonged, debilitating pain and functional impairment. Treatments are not disease-modifying due to the poorly understood underlying pathomechanisms. This study aimed to identify […]

Several studies have demonstrated the influence of religiosity and spirituality (R/S) on patients with chronic diseases. However, few studies have explored the influence of R/S on autoimmune/non-autoimmune rheumatic diseases. We […]

Recent research indicates that macrophages in ganglia are linked to chronic pain, with Piezo2 ion channels playing a key role in pain sensation. Our study aims to elucidate the interplay […]

Chronic low back pain (CLBP) is one of the most common musculoskeletal problems worldwide. Even though regular exercise is recommended as the primary conservative approach in treating this condition, significant […]

One of the primary mechanisms for the increase in range of motion following stretching is an increase in pain/stretch tolerance. However, it remains unclear whether stretching can reduce pain in […]

Utilizing whole-brain functional magnetic resonance imaging(fMRI) to investigate abnormal spontaneous brain activity in the resting state of patients with trigeminal neuralgia (TN) and explore their relationship with pain symptoms and […]

Previous studies have shown that botulinum toxin type A (BoNT-A) attenuates nociception, but the underlying mechanisms remain unclear. Studies of experimental pain in humans have also shown conflicting results. Carrageenan […]

Chronic non-specific low back pain (CNLBP) is a common condition, defined as pain lasting more than 3 months between the lower thoracic margin and gluteal folds, without identifiable tissue damage. Despite […]

Chronic low back pain (LBP), often correlated with intervertebral disc degeneration, is a leading source of disability worldwide yet remains poorly understood. Current treatments often fail to provide sustained relief, […]

This editorial discusses opioid tolerance, a growing challenge in managing pain in chronic patients. With time, overuse of opioids causes less sensitivity and responsiveness of opioid receptors and leads to […]

Endometriosis is a chronic, inflammatory condition where endometrial-like tissue grows outside the uterus, affecting around 10% of women of reproductive age. This condition is associated with debilitating symptoms, including dysmenorrhea, […]