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Effect of adding dexmedetomidine to 0.75% ropivacaine in peribulbar block for vitreoretinal surgery.

Peribulbar anesthesia is suitable for vitreoretinal (VR) surgery. Dexmedetomidine has been used in peribulbar block (PBB) to improve akinesia and analgesia. We aimed to study the efficacy of adding dexmedetomidine to 0.75% Ropivacaine in PBB for VR surgery. The primary outcome was the requirement of block supplementation and secondary outcome was post-operative analgesic requirement.

Molecular Mechanics Simulations and Experimental Investigation of the Effect of Tadalafil on Various Inflammatory Pain Mediators.

Tadalafil's exact analgesic mechanism is still unclear. The current study aimed to elucidate this mechanism in an inflammatory pain model.

Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation.

Intramuscular injection of nerve growth factor as a model of temporomandibular disorder: nature, time-course, and sex differences characterising the pain experience.

A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology.

Low-intensity transcranial focused ultrasound changes pain-associated behaviors by modulating pain processing brain circuits

The impact of sex and physical activity on the local immune response to muscle pain.

A measure of individual differences in the parametric sensitivity of the trigeminal blink reflex.

5-HT1A and 5-HT2B receptor interaction and co-clustering regulates serotonergic neuron excitability.

Dual therapy with Erenumab and onabotulinumtoxinA: no synergistic effect in chronic migraine -A retrospective cohort study.

To assess whether dual therapy with erenumab and onabotulinumtoxinA (BoNTA) was more effective than erenumab alone in chronic migraine.

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