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Papers of the Week


1975 Dec 18


Nature


258


5536

Classic Paper

Identification of two related pentapeptides from the brain with potent opiate agonist activity.

Authors

Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR
Nature. 1975 Dec 18; 258(5536):577-80.
PMID: 1207728.

Abstract

Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.