Complex Regional Pain Syndrome (CRPS)

RESOURCES

IASP members can contact the CRPS SIG Communications Liaison, Amanda Stone, at crps.iasp@gmail.com. Members of the general public should contact IASP at iaspdesk@iasp-pain.org with inquiries about the SIG. The following resources are included to support individuals seeking further information on CRPS. IASP is not responsible for the content listed on these sites.

Research

• International Research Consortium for CRPS
• Core outcome measures for CRPS research studies (COMPACT)

Global Series

Complex regional pain syndrome: abstracts from the International Association for the Study of Pain complex regional pain syndrome SIG virtual symposia 2021 Lewis J, Kashif M, Maan A, Ciampi de Andrade D, Michellef C, Moon J, Lin C, Danielsson Lenai, Quek T, Díez Tafur R, Aloweidi A, Birklein F, Knudsen L, Goebel A PAIN Reports 8(1):p e1056, January 2023.

Local Communities

• United Kingdom: CRPS UK Clinical Research Network
• United States: RSDSA
• Canada: RSD Canada: Promoting Awareness of RSD and CRPS in Canada

Related IASP Global Years

• 2022 Global Year for Translating Pain Knowlege into Practice
• 2018 Global Year for Excellence in Pain Education
• 2017 Global Year Against Pain After Surgery
• 2015 Global Year Against Neuropathic Pain

Articles

A PubMed search revealed a total of 253 publications on CRPS-related issues between January 2022 and Feb 2023. Here are some highlights:

• Complex regional pain syndrome what is the outcome? - a systematic review of the course and impact of CRPS at 12 months from symptom onset and beyond.Johnson S, Cowell F, Gillespie S, Goebel AEur J Pain 2022 Jul 26
• Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, 5th Edition Harden RN, McCabe CS, Goebel A, Massey M, Suvar T, Grieve S, Bruehl SPain Med 2022 Jun 10
• Delphi study to define core clinical outcomes for inclusion in a complex regional pain syndrome international research registry and data bank.Llewellyn A, Buckle L, Grieve S, Birklein F, Brunner F, Goebel A, Harden RN, Bruehl S, Vaughan-Spickers N, Connett R, McCabe CPain 2023 Mar 1
• The Effectiveness of Rehabilitation Interventions on Pain and Disability for Complex Regional Pain Syndrome: A Systematic Review and Meta-analysisShafiee E, MacDermid J, Packham T, Walton D, Grewal R, Farzad MClin J Pain 2023 Feb 1
• Microvascular Barrier Protection by microRNA-183 via FoxO1 Repression: A Pathway Disturbed in Neuropathy and Complex Regional Pain SyndromeReinhold AK, Salvador E, Förster CY, Birklein F, Rittner HLJ Pain 2022 Jun 23
• Substance P Serum Degradation in Complex Regional Pain Syndrome - Another Piece of the Puzzle?König S, Engl C, Bayer M, Escolano-Lozano F, Rittner H, Rebhorn C, Birklein FJ Pain 2022 Mar 23
• Auditory disturbances in patients with complex regional pain syndromeDrummond PD, Finch PMPain 2022 Aug 24
• Stimulation of alpha-1 adrenoceptors may intensify cutaneous inflammation in complex regional pain syndromeWijaya LK, Morici MV, Stumbles PA, Finch PM, Drummond PDPain 2022 Aug 19
• Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter StudyCohen SP, Khunsriraksakul C, Yoo Y, Parker E, Samen-Akinsiku CDK, Patel N, Cohen SJ, Yuan X, Cheng J, Moon JYPain Med 2022 Oct 21
• Evidence- and consensus-based adaption of the IASP complex regional pain syndrome diagnostic criteria to the ICD-11 category of chronic primary pain: a successful cooperation of the IASP with the World Health OrganizationKorwisi, B, Barke, A; Treede, R. PAIN 162(9): p 2313-2314, September 2021.

 

IASP Accepted Criteria for CRPS

"Validation of proposed diagnostic criteria (the “Budapest Criteria”) for complex regional pain syndrome" Harden RN, Bruehl S, Perez RS, Birklein F, Marinus J, Maihofner C, Lubenow T, Buvanendran A, Mackey S, Graciosa J PAIN, 150(2), 268-274.