PRF News

Opioid receptors mediate opioid analgesia and are located throughout the central nervous system (CNS). How they are organized—the cell populations and neural circuits in which they are present—and whether receptor […]

For decades, pain researchers have set their sights on understanding pain mechanisms—the cellular and molecular machinery underlying chronic pain. In doing so, they became increasingly aware that the terms they […]

For decades, researchers have wondered if migraine attacks are somehow tied to the blood-brain barrier. According to one hypothesis, a wave of decreased activity in the cortex, known as “spreading […]

For two decades, the leading theory of phantom limb pain has been that this condition is caused by “maladaptive plasticity.” When the brain’s primary sensorimotor cortex no longer receives input […]

In many acute and chronic pain conditions, pain has a throbbing quality that has long been attributed to the activation of sensory neurons by blood flow pulsations. Now, Andrew Ahn […]