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Going in Opposite Directions: The Role of the Amygdala in Pain

The role of the amygdala in pain has been closely considered by pain researchers for decades. The results have been somewhat contradictory: Recent research has mostly found pronociceptive contributions of […]

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A New Mechanism of Medication-Overuse Headache

It is a cruel irony that the same drugs used to treat migraine headache can themselves cause headache. But the underlying causes of this phenomenon, known as medication-overuse headache (MOH), […]

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A Brain Pathway for Headache Pain Aversiveness

Pain, including migraine pain, can be associated with sensory changes. It can also be an extremely unpleasant experience. But while the sensory characteristics of migraine pain have been examined closely […]

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I Want to Hold Your Hand (to Ease the Pain)

The supportive touch of a romantic partner can have enormous benefits in coping with stressful, threatening, and especially painful situations. To date, the evidence in favor of a role for […]

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What Makes a DRG Neuron a DRG Neuron?

Peripheral sensory neurons are classified based on characteristics such as anatomical structure, physiological responses to stimuli, and expression of gene markers. In a further attempt at classification, a new study […]

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A New Role for Lysozyme in Neuropathic Pain

Lysozyme, a bacteria-gobbling enzyme commonly known for its role in fighting infections as part of the innate immune system, may serve a previously unrecognized role in facilitating chronic pain after […]

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If at First You Don’t Succeed, Try, Try Again: An Improved Strategy to Treat Itch

Everyone knows how unpleasant itch can be, and the relief that comes from scratching. But when it comes to the causes of itch, while acute itch is commonly associated with […]

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Pain Nerve Endings: “Bare” No More

For the past century, dogma has held that unmyelinated nociceptive sensory neurons have “bare” or “free” nerve endings that extend into the epidermis where they detect harmful stimuli directly, unencumbered […]

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“Everybody Has Won and All Must Have Prizes”: Dodo Birds in Psychological Treatments for Chronic Pain

Editor’s note: The following is a summary of the Professor Tess Cramond Named Lecture from the Australian Pain Society 39th Annual Scientific Meeting, which took place from April 7 to […]

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The Mouse Pain Scale: A More Reliable and Unbiased Way to Assess Animal Behavior in Pain Research

Pain is a complex experience that differs from person to person, which makes it challenging to measure objectively in humans. It’s even more difficult to do so in rodents, considering […]

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