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Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine.

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Spontaneous activation of cortical somatosensory networks depresses their excitability in preterm human neonates.

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Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-causing mutations.

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D1RCaMKII in claustrum mediates ACE-induced anxiety and electro-acupuncture therapy.

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Regenerative capacity of neural tissue scales with changes in tissue mechanics post injury.

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Targeting Damaged Collagen for Intra-Articular Delivery of Therapeutics using Collagen Hybridizing Peptides.

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Shear Stress Induces a Pro-Inflammatory Phenotype in Human Monocyte-Derived Macrophages.

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Therapeutic administration of mouse mast cell protease 6 improves functional recovery after traumatic spinal cord injury in mice by promoting remyelination and reducing glial scar formation.

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Critical care nurses’ perceived barriers and enablers of pain assessment and management.

To examine critical care nurses' perceived barriers and enablers of pain assessment and management. This descriptive correlational study recruited a convenience sample of 200 Jordanian nurses. Pain Assessment and Management for the Critically Ill questionnaire was used to measure the study variables. The most common barriers to pain assessment and management were patient inability to communicate (57.5%), patient instability (56.5%), and the lack of protocols/guidelines for pain assessment (55.0%). Whereas the most common enablers for effective pain management practices were the ongoing education on pain for nurses (60.5%) and physicians who prescribe adequate doses of analgesia (60.0%). Addressing nurses' perceived barriers and the enablers of pain assessment and management is crucial for optimal pain practice.

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Regulation of neuroinflammation by astrocyte-derived cholesterol.

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