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Comparison of postoperative analgesia with two different doses of dexmedetomidine as an adjuvant to ropivacaine in adductor canal block for unilateral total knee replacement surgery: A randomized double-blinded study.

Multimodal analgesia is used to treat severe postoperative pain (POP) in total knee replacement (TKR) surgery. Adjuvants are used with local anesthetics to improve the quality and duration of pain relief. Studies comparing different doses of dexmedetomidine in adductor canal block (ACB) are sparse to date. This study compares postoperative analgesia with two different doses of dexmedetomidine as an adjuvant to 0.2% ropivacaine in ACB for unilateral TKR.

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Molecular Mechanics Simulations and Experimental Investigation of the Effect of Tadalafil on Various Inflammatory Pain Mediators.

Tadalafil's exact analgesic mechanism is still unclear. The current study aimed to elucidate this mechanism in an inflammatory pain model.

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Multiple antagonist calcium-dependent mechanisms control CaM Kinase-1 subcellular localization in a C. elegans thermal nociceptor.

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Fetal cannabidiol (CBD) exposure alters thermal pain sensitivity, cognition, and prefrontal cortex excitability.

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Intramuscular injection of nerve growth factor as a model of temporomandibular disorder: nature, time-course, and sex differences characterising the pain experience.

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A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology.

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Low-intensity transcranial focused ultrasound changes pain-associated behaviors by modulating pain processing brain circuits

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The impact of sex and physical activity on the local immune response to muscle pain.

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A measure of individual differences in the parametric sensitivity of the trigeminal blink reflex.

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5-HT1A and 5-HT2B receptor interaction and co-clustering regulates serotonergic neuron excitability.

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