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Papers of the Week


2023 Jan 07


Trials


24


1

Implementation of an evidence-based management algorithm for patients with chronic pancreatitis (COMBO trial): study protocol for a stepped-wedge cluster-randomized controlled trial.

Authors

de Rijk F E, van Veldhuisen CL, Besselink MG, van Hooft JE, van Santvoort HC, van Geenen E J, van Werkhoven CH, de Jonge P JF, Bruno MJ, Verdonk RC
Trials. 2023 Jan 07; 24(1):18.
PMID: 36611202.

Abstract

Chronic pancreatitis (CP) is an inflammatory disease that may be complicated by abdominal pain, pancreatic dysfunction, nutritional deficiencies, and diminished bone density. Importantly, it is also associated with a substantially impaired quality of life and reduced life expectancy. This may partly be explained by suboptimal treatment, in particular the long-term management of this chronic condition, despite several national and international guidelines. Standardization of care through a structured implementation of guideline recommendations may improve the level of care and lower the complication rate of these patients. Therefore, the aim of the present study is to evaluate to what extent patient education and standardization of care, through the implementation of an evidence-based integrated management algorithm, improve quality of life and reduce pain severity in patients with CP.