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Papers of the Week


Papers: 22 Mar 2025 - 28 Mar 2025


2025 Mar 23


Int J Neuropsychopharmacol


40121517

Neuropathic Pain impairs Sleep Architecture, NREM sleep and Reticular Thalamic Neuronal activity.

Authors

López-Canul M, Oveisi A, He Q, Luisa Vigano M, Farina A, Comai S, Gobbi G

Abstract

Neuropathic pain (NP) is a chronic and debilitating condition frequently comorbid with insomnia. However, the alterations in sleep architecture under NP conditions and the mechanisms underlying both pain and sleep disturbances remain poorly understood. The reticular thalamic nucleus (RTN) plays a crucial role in non-rapid eye movement sleep (NREMS) and pain processing, but its involvement in NP-related sleep disruptions has not been fully elucidated.