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Papers of the Week
Paclitaxel alters the microvascular network in the central and peripheral nervous system of rats with chemotherapy-induced painful peripheral neuropathy.
Authors
Zippo AG, Rodriguez-Menendez V, Pozzi E, Canta A, Chiorazzi A, Ballarini E, Monza L, Alberti P, Meregalli C, Bravin A, Coan P, Longo E, Saccomano G, Paiva K, Tromba G, Cavaletti G, Carozzi VAAbstract
Chemotherapy-induced peripheral neurotoxicity (CIPN), with paraesthesia, numbness, dysesthesia and neuropathic pain ranks among the most common dose-limiting toxicity of several widely used anticancer drugs. Recent studies revealed the microvascular angiogenesis as a new important actor, beside peripheral neurons, in the neurotoxicity and neuropathic pain development and chronicisation. The aim of this work is to elucidate the role of vascular alterations in CIPN.