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Papers of the Week
SEX-SPECIFIC DIVERGENCES IN THE TYPES AND TIMING OF INFILTRAING IMMUNE CELL DURING THE INTERVERTEBRAL DISC ACUTE INJURY RESPONSE IS ASSOCIATED WITH REDUCED DEGENERATIVE CHANGES.
Authors
Clayton SW, Walk RE, Mpofu L, Easson GWD, Tang SYAbstract
Inadequate repair of the intervertebral disc (IVD) contributes to low back pain. Infiltrating immune cells into damaged tissues are critical mediators of repair, yet little is known about the identities, roles, and temporal regulation following IVD injury. By analyzing transcripts of immune cell markers, histopathologic analysis, immunofluorescence, and flow cytometry, we aimed to define the temporal cascade of infiltrating immune cells and their associations with IVD degeneration.