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Papers of the Week


Papers: 14 Sep 2024 - 20 Sep 2024


2024 Sep 05


bioRxiv


39282378

Peripheral Inflammation is accompanied by Cerebral Hypoperfusion in Mice.

Authors

Kazeem A, Ge C, Tajerian M

Abstract

Chronic pain is a disabling condition that is accompanied by neuropsychiatric comorbidities such as anxiety, depression, and cognitive decline. While the peripheral alterations are well-studied, we lack an understanding of how these peripheral changes can result in long-lasting brain alterations and the ensuing behavioral phenotypes. This study aims to quantify changes in cerebral blood perfusion using laser speckle contrast imaging (LSCI) in the murine Complete Freund’s adjuvant (CFA) model of unilateral peripheral inflammation.