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Papers of the Week
Non-neuronal cells act as crucial players in neuropathic orofacial pain.
Authors
Iwata K, Hayashi Y, Hitomi S, Tsuboi Y, Shinoda MAbstract
Following peripheral nerve damage, various non-neuronal cells are activated, triggering accumulation in the peripheral and central nervous systems, and communicate with neurons. Evidence suggest that neuronal and non-neuronal cell communication is a critical mechanism of neuropathic pain; however, its detailed mechanisms in contributing to neuropathic orofacial pain development remain unclear.