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Papers of the Week
The role of spinal cord neuroanatomy and the variances of epidurally evoked spinal responses.
Authors
Lam DV, Chin J, Brucker-Hahn MK, Settell M, Romanauski B, Verma N, Upadhye A, Deshmukh A, Skubal A, Nishiyama Y, Hao J, Lujan JL, Zhang S, Knudsen B, Blanz S, Lempka SF, Ludwig KA, Shoffstall AJ, Park HJ, Ellison ER, Zhang M, Lavrov IAbstract
Spinal cord stimulation (SCS) has demonstrated multiple benefits in treating chronic pain and other clinical disorders related to sensorimotor dysfunctions. However, the underlying mechanisms are still not fully understood, including how electrode placement in relation to the spinal cord neuroanatomy influences epidural spinal recordings (ESRs). To characterize this relationship, this study utilized stimulation applied at various anatomical sections of the spinal column, including at levels of the intervertebral disc and regions correlating to the dorsal root entry zone.