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Papers of the Week
Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain.
Authors
Pandey A, Singla M, Geller A, Goodman SB, Bhutani NAbstract
Understanding of pain in osteoarthritis, its genesis, and perception is still in its early stages. Identification of precise ligand-receptor pairs that transduce pain and the cells and tissues in which they reside will elucidate new therapeutic approaches for pain management. Our recent studies had identified an inflammation-amplifying (Inf-A) cell population that is expanded in human OA cartilage and is distinctive in the expression of both IL1R1 and TNF-R2 receptors and active Jnk signaling cascade.