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Papers of the Week
The influence of intervertebral disc overloading on nociceptor calcium flickering.
Authors
Gewiess J, Eglauf J, Soubrier A, Grad S, Alini M, Peroglio M, Ma JAbstract
Mechanical overloading can trigger a degenerative-like cascade in an organ culture of intervertebral disc (IVD). Whether the overloaded IVD can influence the activation of nociceptors (i.e., the damage sensing neurons) remains unknown. The study aims to investigate the influence of overloaded IVD conditioned medium (CM) on the activation of nociceptors.