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Papers: 4 May 2019 - 10 May 2019
Animal Studies, Pharmacology/Drug Development
PAIN TYPE:
Migraine/Headache
2019 May 03
J Headache Pain
20
1
Racemic isometheptene [(RS)-isometheptene] is an antimigraine drug that due to its cardiovascular side-effects was separated into its enantiomers, (R)- and (S)-isometheptene. This study set out to characterize the contribution of each enantiomer to its vasoactive profile. Moreover, rat neurogenic dural vasodilatation was used to explore their antimigraine mechanism of action.