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Atopic dermatitis (AD), chronic eczema and pruritus hiemalis are a set of prevalent chronic xerotic skin disorders which share clinical features such as dryness, scales and pruritus. A ceramide deficiency and defective epidermal functions are common in these diseases. This study was designed to assess the effect of ceramide-linoleic acid (LA-Cer) containing moisturizer as an adjunctive therapy in the treatment of AD, chronic eczema and pruritus hiemalis. In a 2-month study, patients with one of these three diseases were divided into two groups. The control group was treated with mometasone furoate (0.1%) cream (MF), while the treatment group received 0.1% MF in combination with an LA-Cer containing moisturizer. Capacitance (CAP), and transepidermal water loss (TEWL) were measured in normal and lesional skin, along with Eczema Assessment Severity Index (EASI) and pruritus scores at weeks 0, 2, 4, 8. The results showed that tropical applications of an LA-Cer-containing moisturizer in combination with a topical glucocorticoid accelerated the reestablishment of epidermal permeability barrier and the amelioration of pruritus in patients with AD and pruritus hiemalis. However, it did not provide the same effect for chronic eczema. Thus, the efficacy of this combination therapy for this set of xerotic disorders requires further evaluation. This article is protected by copyright. All rights reserved.