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Papers of the Week


Papers: 11 Apr 2020 - 17 Apr 2020


Animal Studies, Pharmacology/Drug Development


2020 Mar 14


J Dermatol Sci

Inhibitory effect of amenamevir on acute herpetic pain and postherpetic neuralgia in mice infected with herpes simplex virus-1.

Authors

Ueda Y, Uta D, Tanbo S, Kawabata A, Kanayama S, Osaki M, Nozawa N, Matsumoto T, Andoh T
J Dermatol Sci. 2020 Mar 14.
PMID: 32284168.

Abstract

Amenamevir (AMNV) is a helicase-primase inhibitor with antiviral activity against herpesviruses [herpes simplex viruses (HSV)-1 and -2, and varicella-zoster virus], which are associated with the development of acute herpetic pain (AHP) and postherpetic neuralgia. However, the inhibitory effects of helicase-primase inhibitors on AHP and postherpetic neuralgia remain incompletely understood.