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Papers of the Week


2020 Aug 22


Mol Genet Genomic Med

A novel genetic variant associated with benign paroxysmal positional vertigo within the LOXL1.

Authors

Deng M, Liu C, Jiang W, Wang F, Zhou J, Wang D, Wang Y
Mol Genet Genomic Med. 2020 Aug 22:e1469.
PMID: 32827243.

Abstract

Benign paroxysmal positional vertigo (BPPV) is a common, self-limited, and favorable prognostic peripheral vestibular disorder. BPPV is transmitted in an autosomal dominant fashion, but most cases occur sporadically. Little research has been reported regarding the mutation spectrum of sporadic BPPV in a large cohort. This study attempted to identify the causative candidate variants associated with BPPV in VDR, LOXL1, and LOXL1-AS1.