Papers of the Week

Multisystem Inflammatory Syndrome in Children (MIS-C) is a recently identified syndrome that appears to be temporally associated with novel coronavirus 2019 infection. MIS-C presents with fever and evidence of systemic inflammation, which can manifest as cardiovascular, pulmonary, neurologic and gastrointestinal system dysfunction. Presenting gastrointestinal symptoms are seen in the majority, including abdominal pain, diarrhea, and vomiting. Any segment of the gastrointestinal tract may be affected, however inflammation in the ileum and colon predominate. Progressive bowel wall thickening can lead to luminal narrowing and obstruction. Most will have resolution of intestinal inflammation with medical therapies, however in rare instances, surgical resection may be required.