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Papers of the Week


2021 Feb 23


Life Sci

LncRNA SNHG15 relieves hyperglycemia-induced endothelial dysfunction via increasing ubiquitination of thioredoxin-interacting protein.

Authors

Zhu Q-Q, Lai M-C, Chen T-C, Wang X, Tian L, Li D-L, Wu Z-H, Wang X-H, He Y-Y, He Y-Y, Shang T, Xiang Y-L, Zhang H-K
Life Sci. 2021 Feb 23:119255.
PMID: 33636173.

Abstract

Numerous evidence indicates that hyperglycemia is a pivotal driver of the vascular complications of diabetes. However, the mechanisms of hyperglycemia-induced endothelial dysfunction in diabetes remain incompletely understood. This study aims to expound on the underlying mechanism of the endothelial dysfunction induced by hyperglycemia from the perspective of long non-coding RNAs (lncRNA).