Attention IASP Members:
Pay Your Dues Online

Interested in Joining?
Learn about Membership

Apply Online Now!

Print This Page

Text Only Site

The Genetics of Pain

Editor: Jeffrey S. Mogil and Foreword by Ronald Dubner

publish year: 2004
hardbound, 349 pages
Progress in Pain Research and Management, Volume 28
ISBN 978-0-931092-51-0

Table of Contents
Read Reviews
Write a Review

CLEARANCE SALE

List Price: US$10.00
IASP members: US$10.00

Buy Now

No field of biology has engendered so much interest, hope, and hype as genetics. Advances in molecular, statistical and behavioral methodologies have suddenly allowed genetic investigations of complex biological phenomena, including pain. Genetic studies of pain are already showing their power to identify new molecular targets for drug development and create new animal models of pain pathology. Alone among biological approaches, pain genetics can explain why we're not all alike with respect to pain - why some people hurt more, and receive less benefit from existing analgesics. The knowledge gained holds the promise of allowing truly individualized pain therapy.

Introduction to Pain Genetics
Jeffrey S. Mogil and Marshall Devor

Part I: Genetic Building Blocks of the Pain System

Studies of Pain Mechanisms in Genetically Manipulated Mice. Annika B. Malmberg and Karla P. Zeitz
Identifying Peripheral Mechanisms of Sensory Hyperexcitability by Antisense Oligodeoxynucleotide - Mediated Gene Targeting. Josephine Lai and Frank Porreca
Microarray Analysis of the Pain Pathway. Michael Costigan, Robert S. Griffin, and Clifford Woolf
Alternative Splicing of Mu-Opioid Receptors. Gavril W. Pasternak and Ying-Xian Pan

Part II: Pain Susceptibility Genes

Individual Differences in Pain: Rat Models. Xiao-Jun Xu and Zsuzsanna Wiesenfeld-Hallin
Complex Trait Genetics of Pain in the Laboratory Mouse. Jeffrey S. Mogil
The Heritability of Pain in Humans. Alex J. MacGregor
Congenital Insensitivity to Pain. Yasuhiro Indo
Migraine Genetics. Joost Haan, Arn M.J.M. van den Maagdenberg, Aarno Palotie, and Michel D. Ferrari
Pharmacogenetics, Pharmacokinetics, and Analgesia. Jules A. Desmeules, Valerie Piguet, Georg B. Ehret, and Pierre Dayer
Pharmacogenetics: The OPRM (Mu-Opioid-Receptor) Gene. Lei Yu

Part III: Complexities, Opportunities, and Worries

Gene-Environment Interactions Affecting Pain Phenotype: Animal Studies. Jeffrey S. Mogil, Ze'ev Seltzer, and Marshall Devor
Social and Environmental Influences on Pain: Implications for Pain Genetics. Roger B. Fillingim
Gene Therapy for Pain. David C. Yeomans and Steven P. Wilson
Ethics and the Genetics of Pain. Margaret A. Somerville

Reviews

"...The Genetics of Pain is a timely book that provides an informative and comprehensive summary of the latest advances in genetics as well as the possible implications for treatment. The book is edited by one of the leading researchers in the field of pain genetics and is written by nearly thirty international experts in the pain field with experience in different areas of animal and human genetic research. These authors present the latest information on a range of topics from genetic techniques and terminology through to summaries of genetic studies in animals and humans, and potential clinical applications.

"As far as I am aware, there is no comparable volume and certainly none that brings together such expertise and authority in an area of research that is so topical. This book is a tremendous resource at a reasonable price. I would highly recommend it for any medical library and for the shelf of anyone that has an interest in pain medicine and wants to get a handle on what part genetics may play."
P. Siddall in Anaesthesia and Intensive Care, Vol. 33, No. 5, October 2005

"This is an exciting and important book that opens new vistas in the world of pain."
Alan R. Light in APS [American Pain Society] Bulletin, Nov/Dec 2004

"...an excellent introduction to the filed for non-geneticists interested in the genetics of pain and ...a valuable entry point into the field of pain research for those already working in genetics."
Simon C. Harvey, Palliative Medicine 2005 #19

"Overall, this volume, edited by Jeffrey Mogil, is will written and provides a good overview of the genetics of pain. The new investigator with a basic interest in understanding how genes (and environmental factors) influence pain phenotypes and the seasoned researcher interested in the intricate roles of various receptors in pain phenotypes would benefit from reading this volume."
Genes, Brain and Behavior (2006) 5: 111, reviewed by Melloni N. Cook