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Papers of the Week

January 27, 2023

Front Mol Neurosci



VTA-NAc glutaminergic projection involves in the regulation of pain and pain-related anxiety.


Abdul M, Yan H-Q, Zhao W-N, Lyu X-B, Xu Z, Yu X-L, Gao Y-H, Cao J-L
Front Mol Neurosci. 2022; 15:1083671.
PMID: 36590915.


Besides the established role of dopamine neurons and projections in nociceptive stimuli, the involvement of ventral tegmental area (VTA) glutamatergic projections to nucleus accumbens (NAc) in pain remains unknown. In the present study, we aimed to examine the role of VTA glutamatergic projections to NAc in painful stimuli and its related behavioral changes.