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Papers of the Week


January 27, 2023


Psychopharmacology (Berl)


http://www.ncbi.nlm.nih.gov/pubmed/36648509?dopt=Abstract

Unravelling the dorsal periaqueductal grey matter NMDA receptors relevance in the nitric oxide-mediated panic‑like behaviour and defensive antinociception organised by the anterior hypothalamus of male mice.

Authors

Falconi-Sobrinho L L, Dos Anjos-Garcia T, Hernandes P M, de Rodrigues B M P, Almada R C, Coimbra N C
Psychopharmacology (Berl). 2023 Jan 17.
PMID: 36648509.

Abstract

Previous studies suggested that the dorsal column of the periaqueductal grey matter (dPAG) can be a target of neural pathways from hypothalamic nuclei involved in triggering fear-related defensive responses. In turn, evidence is provided suggesting that microinjection of the nitric oxide (NO) donor SIN-1 into the anterior hypothalamus (AH) of mice evokes panic-like behaviours and fear-induced antinociception. However, it is unknown whether the dPAG of mice mediates these latter defensive responses organised by AH neurons.