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Papers of the Week


January 27, 2023


Molecules


http://www.ncbi.nlm.nih.gov/pubmed/36557779?dopt=Abstract


27


24

Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification.

Authors

Zhang C, Zhang S, Liao J, Gong Z, Chai X, Lyu H
Molecules. 2022 Dec 07; 27(24).
PMID: 36557779.

Abstract

Sinomenine is the main component of the vine . It was first isolated in the early 1920s and has since attracted special interest as a potential anti-rheumatoid arthritis (RA) agent, owing to its successful application in traditional Chinese medicine for the treatment of neuralgia and rheumatoid diseases. In the past few decades, significant advances have broadened our understanding of the molecular mechanisms through which sinomenine treats RA, as well as the structural modifications necessary for improved pharmacological activity. In this review, we summarize up-to-date reports on the pharmacological properties of sinomenine in RA treatment, document their underlying mechanisms, and provide an overview of promising sinomenine derivatives as potential RA drug therapies.