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Papers of the Week


January 27, 2023


Pharmaceuticals (Basel)


http://www.ncbi.nlm.nih.gov/pubmed/36558990?dopt=Abstract


15


12

Segmental Upregulation of ASIC1 Channels in the Formalin Acute Pain Mouse Model.

Authors

Natalia Gobetto M, Castellanos L C S, Contreras N E, Sodero A O, Cambiagno D A, Malnati G O M, Montes M M, Uchitel O D, Weissmann C
Pharmaceuticals (Basel). 2022 Dec 12; 15(12).
PMID: 36558990.

Abstract

Hindpaw injection of formalin in rodents is used to assess acute persistent pain. The response to formalin is biphasic. The initial response (first minutes) is thought to be linked to inflammatory, peripheral mechanisms, while the latter (around 30 min after the injection), is linked to central mechanisms. This model is useful to analyze the effect of drugs at one or both phases, and the involvement of ion channels in the response. Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in pain conditions. Recently, psalmotoxin-1 (Pctx-1), a toxin that inhibits ASIC1a-constituted channels, and antisense ASIC1a-RNA, intrathecal administered in mice were shown to affect both phases of the test.