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Papers of the Week

January 27, 2023

J Neurosurg Pediatr


Postoperative seizure freedom after vagus nerve stimulator placement in children 6 years of age and younger.


Maleknia P, McWilliams TD, Barkley A, Estevez-Ordonez D, Rozzelle C, Blount JP
J Neurosurg Pediatr. 2023 Jan 20:1-4.
PMID: 36670534.


Food and Drug Administration (FDA) approval for vagus nerve stimulator (VNS) implantation is limited to patients older than 4 years of age with medically refractory partial-onset seizures. In younger children with severe generalized epilepsy, however, VNS implantation remains off-label. In this study, the authors followed up on their previously reported cohort to review the longer-term safety and efficacy of VNS placement in children younger than 6 years with generalized medically refractory epilepsy (MRE), providing the largest cohort with > 2 years of follow-up to date in this age group.