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Papers of the Week

January 27, 2023

Front Vet Sci



Pharmacokinetics of cannabidiol following single oral and oral transmucosal administration in dogs.


Della Rocca G, Paoletti F, Conti M B, Galarini R, Chiaradia E, Sforna M, Dall'Aglio C, Polisca A, Di Salvo A
Front Vet Sci. 2022; 9:1104152.
PMID: 36686155.


In the last few years, different formulations containing cannabidiol (CBD) were tested with regard to its efficacy on chronic pain, refractory epilepsy, anxiety, aggressive behavior and atopic dermatitis in dogs. CBD is generally administered orally, but its low bioavailability, probably due to a first-pass metabolism, represents a great limitation. The aim of this study was to evaluate if CBD bioavailability increases after oral transmucosal administration (OTM) compared to oral treatment.