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Papers of the Week


January 27, 2023


Front Vet Sci


http://www.ncbi.nlm.nih.gov/pubmed/36686155?dopt=Abstract


9

Pharmacokinetics of cannabidiol following single oral and oral transmucosal administration in dogs.

Authors

Della Rocca G, Paoletti F, Conti M B, Galarini R, Chiaradia E, Sforna M, Dall'Aglio C, Polisca A, Di Salvo A
Front Vet Sci. 2022; 9:1104152.
PMID: 36686155.

Abstract

In the last few years, different formulations containing cannabidiol (CBD) were tested with regard to its efficacy on chronic pain, refractory epilepsy, anxiety, aggressive behavior and atopic dermatitis in dogs. CBD is generally administered orally, but its low bioavailability, probably due to a first-pass metabolism, represents a great limitation. The aim of this study was to evaluate if CBD bioavailability increases after oral transmucosal administration (OTM) compared to oral treatment.