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Papers of the Week


January 27, 2023


Neurol Sci


http://www.ncbi.nlm.nih.gov/pubmed/36622478?dopt=Abstract

Neurological sequelae of vaccines.

Authors

McAlpine LS, Zubair AS
Neurol Sci. 2023 Jan 09.
PMID: 36622478.

Abstract

Vaccines are a safe and efficacious way to prevent a variety of infectious diseases. Over the course of their existence, vaccines have prevented immeasurable morbidity and mortality in humans. Typical symptoms of systemic immune activation are common after vaccines and may include local soreness, myalgias, nausea, and malaise. In the vast majority of cases, the severity of the infectious disease outweighs the risk of mild adverse reactions to vaccines. Rarely, vaccines may be associated with neurological sequela that ranges in severity from headache to transverse myelitis, acute disseminated encephalomyelitis, and Guillain-Barre syndrome (GBS). Often, a causal link cannot be confirmed, and it remains unclear if disease onset is directly related to a recent vaccination.