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Papers of the Week


January 27, 2023


Br J Pharmacol


http://www.ncbi.nlm.nih.gov/pubmed/36585367?dopt=Abstract

Morphine use induces gastric microbial dysbiosis driving gastric inflammation through TLR2 signaling which is attenuated by proton pump inhibitor.

Authors

Ghosh N, Kesh K, Singh P K, Sharma U, Chupikova I, Ramakrishnan S, Roy S
Br J Pharmacol. 2022 Dec 30.
PMID: 36585367.

Abstract

Opioids are the gold standard drug for pain management, however, their effect on gastric dysfunction is relatively understudied. Opioid users have a higher incidence of gastric pathology leading to increased hospitalization. Herein, we investigated the consequence of morphine use on gastric pathology and the underlying mechanisms. We further investigated the therapeutic benefit of proton pump inhibition as a pharmacological target to overcome morphine-mediated gastric inflammation.