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Papers of the Week


January 1, 2023


Lancet HIV


http://www.ncbi.nlm.nih.gov/pubmed/36566079?dopt=Abstract


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Lenacapavir administered every 26 weeks or daily in combination with oral daily antiretroviral therapy for initial treatment of HIV: a randomised, open-label, active-controlled, phase 2 trial.

Authors

Gupta SK, Berhe M, Crofoot G, Benson P, Ramgopal M, Sims J, McDonald C, Ruane P, Sanchez WE, Scribner A, Liu S-Y, VanderVeen LA, Dvory-Sobol H, Rhee MS, Baeten JM, Koenig E
Lancet HIV. 2023 Jan; 10(1):e15-e23.
PMID: 36566079.

Abstract

Antiretroviral agents with novel mechanisms and dosing intervals could expand treatment options for people with HIV. Lenacapavir, an inhibitor of capsid protein that makes use of a unique mechanism, can be administered orally or subcutaneously. We sought to explore the efficacy of lenacapavir in various combination regimens as initial and maintenance therapy for HIV.