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Papers of the Week


January 27, 2023


iScience


http://www.ncbi.nlm.nih.gov/pubmed/36567707?dopt=Abstract


25


12

Glial regulators of ions and solutes required for specific chemosensory functions in C. elegans

Authors

Wang L, Graziano B, Encalada N, Fernandez-Abascal J, Kaplan DH, Bianchi L
iScience. 2022 Dec 22; 25(12):105684.
PMID: 36567707.

Abstract

Glia and accessory cells regulate the microenvironment around neurons and primary sensory cells. However, the impact of specific glial regulators of ions and solutes on functionally diverse primary cells is poorly understood. Here, we systemically investigate the requirement of ion channels and transporters enriched in Amsh glia for the function of chemosensory neurons. Although Amsh glia ablated worms show reduced function of ASH, AWC, AWA, and ASE neurons, we show that the loss of glial enriched ion channels and transporters impacts these neurons differently, with nociceptor ASH being the most affected. Furthermore, our analysis underscores the importance of K, Cl, and nucleoside homeostasis in the Amphid sensory organ and uncovers the contribution of glial genes implicated in neurological disorders. Our findings build a unique fingerprint of each glial enriched ion channel and transporter and may provide insights into the function of supporting cells of mammalian sensory organs.