I am a
Home I AM A Search Login

Papers of the Week

Papers: 13 May 2023 - 19 May 2023

Basic Science

Animal Studies, Molecular/Cellular, Pharmacology/Drug Development

Inflammation/Inflammatory, Itch

2023 May 16

Life Sci


FSLLRY-NH, a protease-activated receptor 2 (PAR2) antagonist, activates mas-related G protein-coupled receptor C11 (MrgprC11) to induce scratching behaviors in mice.


In Kim H, Lee GB, Song DE, Sanjel B, Lee WJ, Shim WS


Protease-activated receptor 2 (PAR2), a type of G protein-coupled receptor (GPCR), plays a significant role in pathophysiological conditions such as inflammation. A synthetic peptide SLIGRL-NH (SLIGRL) can activate PAR2, while FSLLRY-NH (FSLLRY) is an antagonist. A previous study showed that SLIGRL activates both PAR2 and mas-related G protein-coupled receptor C11 (MrgprC11), a different type of GPCR expressed in sensory neurons. However, the impact of FSLLRY on MrgprC11 and its human ortholog MRGPRX1 was not verified. Hence, the present study aims to verify the effect of FSLLRY on MrgprC11 and MRGPRX1.