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Papers of the Week

January 27, 2023

Sleep Med



Effect of mini-dose dexmedetomidine supplemented intravenous analgesia on sleep structure in older patients after major noncardiac surgery: A randomized trial.


Zhang Z-F, Su X, Zhao Y, Zhong C-L, Mo X-Q, Zhang R, Wang K, Zhu S-N, Shen Y-E, Zhang C, Wang D-X
Sleep Med. 2022 Dec 20; 102:9-18.
PMID: 36587547.


In previous studies, low-dose dexmedetomidine supplemented opioid analgesia improved sleep architecture but increased sedation level. Herein we tested the hypothesis that mini-dose dexmedetomidine supplemented analgesia improves sleep structure without increasing sedation.