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Papers of the Week


Papers: 24 Dec 2022 - 30 Dec 2022


January 26, 2023


Princ Pract Clin Res


http://www.ncbi.nlm.nih.gov/pubmed/36561218?dopt=Abstract


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Cost-Effectiveness Analysis to Inform Randomized Controlled Trial Design in Chronic Pain Research: Methods for Guiding Decisions on the Addition of a Run-In Period.

Authors

Rafferty H, Rocha E, Gonzalez-Mego P, Ramos CL, El-Hagrassy MM, Gunduz ME, Uygur-Kucukseymen E, Zehry H, Chaudhari SS, Teixeira PEP, Rosa GR, Zaninotto AL, Connor C, Eden U, Ramos-Estebanez C, Fregni F, Dipietro L, Wagner T
Princ Pract Clin Res. 2022 Jul 03; 8(2):31-42.
PMID: 36561218.

Abstract

Run-In (RI) periods can be used to improve the validity of randomized controlled trials (RCTs), but their utility in Chronic Pain (CP) RCTs is debated. Cost-effectiveness analysis (CEA) methods are commonly used in evaluating the results of RCTs, but they are seldom used for designing RCTs. We present a step-by-step overview to objectively design RCTs via CEA methods and specifically determine the cost effectiveness of a RI period in a CP RCT.