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Papers of the Week


January 27, 2023


Front Immunol


http://www.ncbi.nlm.nih.gov/pubmed/36578487?dopt=Abstract


13

Circulating monocytes in acute pancreatitis.

Authors

Liu S, Szatmary P, Lin J-W, Wang Q, Sutton R, Chen L, Liu T, Huang W, Xia Q
Front Immunol. 2022; 13:1062849.
PMID: 36578487.

Abstract

Acute pancreatitis is a common gastrointestinal disease characterized by inflammation of the exocrine pancreas and manifesting itself through acute onset of abdominal pain. It is frequently associated with organ failure, pancreatic necrosis, and death. Mounting evidence describes monocytes – phagocytic, antigen presenting, and regulatory cells of the innate immune system – as key contributors and regulators of the inflammatory response and subsequent organ failure in acute pancreatitis. This review highlights the recent advances of dynamic change of numbers, phenotypes, and functions of circulating monocytes as well as their underling regulatory mechanisms with a special focus on the role of lipid modulation during acute pancreatitis.